Soft Actuator and Sensor for Underactive Bladder Treatment

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Researchers at the National University of Singapore have developed a soft sensor and actuator to monitor bladder volume and help empty it on-demand. The device is intended to be implanted on the bladder surface during a surgical procedure to treat patients who cannot completely empty their bladders voluntarily.

Patients can suffer from an underactive bladder following a spinal cord injury, meaning that they cannot easily sense when the bladder is full, or completely empty it. Approximately 80% of patients who suffer a spinal cord injury will demonstrate some bladder dysfunction. Not only is this inconvenient and upsetting for patients, but it can lead to various issues such as urinary tract infections.

There is
currently no effective treatment for the condition, with current implantable
devices only emptying the bladder up to 43% of their full volume. “To help
these patients, what clinicians need is an integrated bladder system that
achieves both volume sensing capability and high voiding efficiency,” said Nitish
Thakor, a researcher involved in the study. “Given that the urinary bladder is
unique among human organs as it undergoes large volume changes during the
storage and urination phases, the device requires careful compatibility
considerations to avoid interference with the extreme volume changes of the
bladder.”

To address
this, these researchers have developed a new soft device incorporating a sensor
that can monitor urine volumes in the bladder, and an actuator that can apply gentle
pressure to the bladder during urination. The sensor contains a shape memory
spring to ensure that it maintains constant contact with the bladder surface,
where it can infer how full the bladder is.

So far, the
research team has shown that the device can help to empty the bladder by
70–100%. “This is a significant achievement as its performance is comparable to
the efficiency of intermittent catheterization treatment currently being used,
which has many shortcomings,” said Dr Arab Hassani, a researcher involved
study. “We need a soft but efficient device to help a weak bladder.”    

Strikingly,
the device may have potential for manipulating other organs and structures
within the body for therapeutic effects. “Our soft system demonstrated on a
bladder can serve as a model for augmenting other organs as well,” said Thakor.
“I believe this novel design can pave the way for the development of sensors
and actuators that are compatible with other soft and distensible organs like
blood vessels, the heart, and the gastrointestinal system, as these organs
require both sensing and actuation to achieve functions like pumping and
peristalsis under soft actuation and control.”

Study in Science
Advances
: Soft sensors for a
sensing-actuation system with high bladder voiding efficiency

Via: National
University of Singapore





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